Sunday, October 19, 2025

Apoptosis at Inflection Point in Liquid Culture of Budding Yeasts

Authors: Toshiyuki Hagiwara, Takashi Ushimaru, Kei-ichi Tainaka, Hironori Kurachi, Jin Yoshimura

DOI: 10.1371/journal.pone.0019224

Abstract Summary

Researchers discovered that aging yeast cells undergo programmed cell death (apoptosis) after just 6 cell divisions in liquid culture – much earlier than the 20-30 divisions seen on solid media. By tracking “bud scars” that mark each division, they found older cells mysteriously disappeared, with microscopy revealing cell breakage.

Why Brain? 🧠

Study reveals budding yeast cells undergo programmed cell death (apoptosis) after 6+ divisions in liquid culture, contradicting expected cell counts and suggesting aging limits.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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