Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study.

Authors: Turolo S, Edefonti A, Syren ML, Bellotti AS, Morello W, Collino F, Agostoni C, Montini G.

DOI: 10.3389/fphar.2025.1672304

Abstract Summary

New research reveals that mycophenolic acid levels in children with steroid-sensitive nephrotic syndrome correlate with beneficial shifts in cellular fatty acids—increasing anti-inflammatory omega-3s while decreasing omega-6s. This favorable ratio may enhance the drug’s therapeutic effects. However, steroid-resistant patients showed no such benefit, suggesting different disease mechanisms at play.

Why Brain? 🧠

Study reveals mycophenolic acid therapy in steroid-sensitive nephrotic syndrome children increases anti-inflammatory omega-3 fatty acids in immune cells, potentially explaining treatment benefits.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.