Authors: Jacobsen L, Fernandes DM, Nagel ML, Souza EL, Viana DPDC.
DOI: 10.3390/jcm15010048
Abstract Summary
Estradiol pellets provide sustained hormone release for 4-6 months, bypassing liver metabolism and maintaining near-physiological hormone ratios. A 25mg dose effectively controls menopausal symptoms and supports bone health with favorable metabolic profiles. Best suited for women with poor transdermal absorption or low adherence, safety requires individualized dosing and endometrial protection.
Why Brain? ๐ง
Subcutaneous estradiol pellets provide stable hormone levels for 4-6 months, bypassing liver metabolism with favorable safety when properly dosed, offering an alternative for women with poor transdermal absorption.
Study Limitations:
Narrative review design limits strength of evidence compared to systematic review or meta-analysis.
Long-term comparative studies are lacking to standardize protocols and support broader evidence-based use.
License: cc by.
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