Authors: Kristine O. Vasquez, Chelsea Casavant, Jeffrey D. Peterson
DOI: 10.1371/journal.pone.0020594
Abstract Summary
Fluorescence molecular tomography (FMT) enables non-invasive, real-time tracking of drug distribution in living animals, similar to radiotracer methods. Researchers validated FMT by imaging four fluorescent agents over 24 hours in mice, showing distinct clearance patterns: nanoparticles and antibodies accumulated in liver, while small molecules cleared rapidly through kidneys.
Why Brain? ðŸ§
Non-invasive fluorescence imaging accurately tracks drug distribution in living animals over time, enabling real-time pharmacokinetic studies without sacrificing subjects or using radioactive tracers.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
