Authors: Anne-France Petit-Bertron, François Machavoine, Marie Paule Defresne, Michel Gillard, Pierre Chatelain, Prakash Mistry, Elke Schneider, Michel Dy
DOI: 10.1371/journal.pone.0006504
Abstract Summary
The H4 histamine receptor, found on blood-forming stem cells, slows cell division when activated—protecting these cells from chemotherapy damage. Researchers showed that H4R activation pauses progenitor cells in their growth cycle without killing them, shielding them from Ara-C chemotherapy toxicity in lab tests and reducing bone marrow damage in mice. This discovery could lead to new strategies for protecting patients’ healthy blood cells during cancer treatment.
Why Brain? 🧠
H4 histamine receptor activation halts blood cell progenitor division, protecting them from chemotherapy toxicity. This discovery could lead to treatments reducing bone marrow damage during cancer therapy.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
