Authors: Cianga VA, Antohe I, Minciună C, Dăscălescu A.
DOI: 10.3389/fphar.2025.1738558
Abstract Summary
CAR-NK cells offer safer, more versatile cancer immunotherapy than CAR-T cells. This review uniquely maps tumor escape mechanisms—like antigen loss and immune evasion—to targeted engineering solutions including dual-antigen CARs and advanced gene editing. The framework provides a translational roadmap for designing resilient next-generation CAR-NK therapies.
Why Brain? 🧠
CAR-NK cells offer safer cancer immunotherapy than CAR-T cells. This review maps tumor escape mechanisms to engineering solutions, providing a strategic framework for designing more effective treatments.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
