Authors: Gao L, Smith N, Kong R.
DOI: 10.3389/fphar.2025.1701617
Abstract Summary
Study reveals BH4, a crucial enzyme cofactor, follows a circadian rhythm peaking in evening hours. Analysis of 1,175 measurements showed healthy males have higher levels than females, with variations across races. BH4 concentrations differ significantly between healthy adults, PKU patients, and those with primary BH4 deficiency, suggesting diagnostic potential. Morning measurements (7-11 AM) offer optimal stability for clinical testing.
Why Brain? ðŸ§
Study reveals BH4 levels vary by time of day, sex, and race in healthy adults, with lowest morning levels ideal for testing. BH4 differences may aid diagnosis of metabolic disorders.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
