Authors: Ulrike Böer, Tahseen Alejel, Stephan Beimesche, Irmgard Cierny, Doris Krause, Willhart Knepel, Gabriele Flügge
DOI: 10.1371/journal.pone.0000431
Abstract Summary
Researchers created transgenic mice to track CREB transcription factor activity in the brain. Chronic social stress increased CREB-driven gene expression by 45-120% across brain regions, while antidepressant treatment normalized these levels. The findings suggest CREB plays a key role in stress-related depression and antidepressant action works by modulating CREB-directed gene transcription.
Why Brain? 🧠
Transgenic mice reveal chronic stress increases CREB-driven brain gene expression by up to 120%, while antidepressant treatment reverses these changes, supporting CREB’s role in depression mechanisms.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
