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Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

Authors: Abhisek Mukherjee, Diego Morales-Scheihing, Dennisse Gonzalez-Romero, Kristi Green, Giulio Taglialatela, Claudio Soto DOI: 10.1371/journal.ppat.1001138 Abstract Summary Researchers found that blocking the enzyme Calcineurin with drug FK506 extended survival and reduced neurodegeneration in prion-infected...

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