Saturday, February 7, 2026

Immune Checkpoint Inhibitor Therapy in Hormone Receptor-Positive Breast Cancer.

Authors: Lin D, Bitar JSL, Ma I, Yuan Y.

DOI: 10.3390/ijms262412171

Abstract Summary

Immune checkpoint inhibitors have revolutionized triple-negative breast cancer treatment, but HR+/HER2- tumors remain challenging due to poor immunogenicity. New combination strategies aim to transform “cold” tumors into “hot” ones. Early trials show promise in high-risk HR+ cases, but more data is needed.

Why Brain? 🧠

Novel immunotherapy combinations show promise in converting “cold” HR+ breast cancers to “hot” tumors, potentially improving treatment outcomes, though more long-term data needed before routine clinical use.

License: cc by.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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