Authors: Doering E, Hoenig MC, Cole JH, Drzezga A.
DOI: 10.2967/jnumed.125.270325
Abstract Summary
Brain age gap (BAG)โthe difference between measured brain age via neuroimaging and chronological ageโoffers promising biomarkers for neurodegenerative diseases. While such diseases aren’t simply accelerated aging, they produce similar brain changes detectable by machine learning models across multiple imaging modalities: structural MRI, metabolic PET, functional MRI, and diffusion MRI. Each provides unique insights into disease progression, particularly in Alzheimer’s disease.
Why Brain? ๐ง
Brain age gap (BAG) from neuroimaging reveals accelerated aging in neurodegeneration, offering biomarkers for Alzheimer’s monitoring and evaluating therapeutic interventions across MRI modalities.
Study Limitations:
Single-center study design not explicitly mentioned.
Small sample size not explicitly mentioned.
License: cc by.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
