Authors: Teresa Jacobson Kimberley, Richard P. Di Fabio
DOI: 10.1371/journal.pone.0015155
Abstract Summary
Single-subject analysis revealed significant cortical excitability changes in 4 of 5 focal hand dystonia patients after repetitive TMS treatment, while traditional group statistics detected nothing. This study highlights how individual-level statistical approaches can capture treatment responses that group analyses miss, offering researchers a more sensitive method to assess TMS outcomes despite small sample sizes and variable patient responses.
Why Brain? ðŸ§
Study demonstrates single-subject analysis detects brain stimulation effects in dystonia patients that group statistics miss, offering better approach for small clinical samples with variable responses.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
