Authors: Hilda Fragoso-Loyo, Javier Cabiedes, Alejandro Orozco-Narváez, Luis Dávila-Maldonado, Yemil Atisha-Fregoso, Betty Diamond, Luis Llorente, Jorge Sánchez-Guerrero
DOI: 10.1371/journal.pone.0003347
Abstract Summary
Researchers found that in lupus patients with neuropsychiatric symptoms, blood autoantibodies don’t predict brain involvement. However, anti-NMDAR antibodies in spinal fluid specifically identified central nervous system lupus. These antibodies persisted six months after symptoms, raising questions about when they actually cause disease versus simply being present.
Why Brain? 🧠
Study finds anti-NMDAR antibodies in spinal fluid, not blood, identify lupus brain involvement, challenging diagnosis methods and suggesting these antibodies persist even after symptoms improve.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
