Authors: Dengri C, Mayberry W, Koriesh A, Nouh A.
DOI: 10.1007/s11910-025-01426-6
Abstract Summary
Testosterone and androgen signaling show complex effects on neurological healthโboth protective and harmful depending on dosage and context. While testosterone replacement therapy shows experimental promise for conditions like multiple sclerosis, Parkinson’s, and epilepsy, androgen-blocking may benefit spinal muscular atrophy. However, no treatments are yet approved for neurological use, and risks exist: excessive testosterone supplementation and prenatal exposure may harm neurodevelopment, while androgen-blocking could increase dementia risk. Rigorous clinical trials are needed to establish safety and efficacy.
Why Brain? ๐ง
Testosterone shows promise in treating MS, epilepsy, and Parkinson’s disease, but can harm at high doses or prenatally. More trials needed to confirm safety and efficacy in neurological disorders.
Study Limitations:
Study limitations were not specified in the abstract.
License: cc by.
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