Authors: Biaoyang Lin, Anup Madan, Jae-Geun Yoon, Xuefeng Fang, Xiaowei Yan, Taek-Kyun Kim, Daehee Hwang, Leroy Hood, Gregory Foltz
DOI: 10.1371/journal.pone.0010210
Abstract Summary
Researchers used advanced sequencing to identify 4,535 genes with altered expression in glioblastoma multiforme (GBM). They discovered two alternative TGF-β signaling pathways mediated by SOX4 and TGFBI proteins, which are elevated in GBM tumors. These non-SMAD pathways represent potential new therapeutic targets for treating this aggressive brain cancer.
Why Brain? 🧠
Study identifies new TGF-β signaling pathways in glioblastoma through advanced sequencing, revealing SOX4 and TGFBI as potential therapeutic targets beyond traditional SMAD pathways for this deadly brain cancer.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
