Authors: Ligang Wang, Hongkuan Yang, Shiguang Zhao, Haruhisa Sato, Yoshihiro Konishi, Thomas G. Beach, Essam Mohamed Abdelalim, Naomi J. Bisem, Ikuo Tooyama
DOI: 10.1371/journal.pone.0022325
Abstract Summary
Mitochondrial ferritin (MtF) levels are significantly elevated in Alzheimer’s disease brains, primarily in neurons. Research shows MtF increases in response to oxidative stress and protects cells against damage. This suggests MtF plays a neuroprotective role in AD, potentially serving as a cellular defense mechanism against oxidative injury.
Why Brain? ðŸ§
Mitochondrial ferritin increases in Alzheimer’s brain tissue and protects neurons from oxidative stress, suggesting it may be a protective response to disease progression and potential therapeutic target.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
