Evidence of Key Tinnitus-Related Brain Regions Documented by a Unique Combination of Manganese-Enhanced MRI and Acoustic Startle Reflex Testing

Authors: Avril Genene Holt, David Bissig, Najab Mirza, Gary Rajah, Bruce Berkowitz

DOI: 10.1371/journal.pone.0014260

Abstract Summary

Researchers combined behavioral testing and manganese-enhanced MRI to identify brain biomarkers in rat tinnitus models. Both salicylate- and noise-induced tinnitus showed abnormal neuronal activity in the inferior colliculus, suggesting this region plays a key role in tinnitus. This breakthrough provides new tools for tracking tinnitus severity and testing treatments in animal studies.

Why Brain? 🧠

Study identifies inferior colliculus as key brain region in tinnitus using novel imaging technique, providing new biomarker for testing treatments in animal models and understanding tinnitus mechanisms.

License: CC BY.

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