Authors: Filip Simunovic, Ming Yi, Yulei Wang, Robert Stephens, Kai C. Sonntag
DOI: 10.1371/journal.pone.0008856
Abstract Summary
Gene expression analysis of dopamine neurons reveals gender-specific molecular differences in Parkinson’s disease. Male PD patients show more severe downregulation of genes involved in energy production, cell survival, and nerve signaling compared to females. These molecular distinctions may explain why men face higher PD risk and different disease progression.
Why Brain? ðŸ§
Study reveals male and female Parkinson’s patients show distinct gene expression patterns in dopamine neurons, with males displaying greater dysfunction in key cellular pathways, potentially explaining why men face higher disease risk.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
