Authors: Duong P. Huynh, Marwan Maalouf, Alcino J. Silva, Felix E. Schweizer, Stefan M. Pulst
DOI: 10.1371/journal.pone.0006235
Abstract Summary
Ataxin-2 knockout mice show impaired fear responses and motor hyperactivity while maintaining normal memory function. These mice exhibit defective neural plasticity in the amygdala but not the hippocampus, resulting in reduced fear conditioning yet intact spatial learning. This unique model offers new insights into anxiety disorders and suggests SCA2 patients warrant anxiety screening.
Why Brain? đź§
Ataxin-2 knockout mice show impaired amygdala function affecting fear responses while maintaining normal hippocampal learning, offering a unique model for studying anxiety disorders and SCA2 patients.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
