Authors: Tai XY, Toniolo S, Llewellyn DJ, van Duijn CM, Husain M, Manohar SG.
DOI: 10.1093/braincomms/fcaf307
Abstract Summary
Researchers analyzing UK Biobank data from 497,252 participants found distinct pre-diagnosis cognitive decline patterns across neurological diseases. Epilepsy and multiple sclerosis showed gradual executive function decline up to 15 years before diagnosis, while stroke exhibited sharp decline at diagnosis. Migraine patients showed mild pre-diagnosis impairment that improved post-diagnosis. Brain imaging revealed reduced grey matter before diagnosis in stroke, Parkinson’s, and MS.
Why Brain? ๐ง
Study reveals cognitive decline begins years before diagnosis in multiple neurological conditions, with disease-specific patterns detected up to 15 years early, potentially enabling earlier intervention.
Study Limitations:
Study limitations were not specified in the abstract.
License: cc by.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
