Authors: Chuancheng Ren, Xuwen Gao, Gang Niu, Zhimin Yan, Xiaoyuan Chen, Heng Zhao
DOI: 10.1371/journal.pone.0003851
Abstract Summary
Researchers discovered that “delayed postconditioning”—brief, repetitive blood flow interruptions performed 3-6 hours after stroke—significantly reduces brain damage in rats. This technique improved long-term outcomes for up to two months and even counteracted harmful side effects of tPA clot-busting therapy. Unlike immediate postconditioning with impractically narrow treatment windows, this delayed approach offers a more clinically feasible neuroprotective strategy.
Why Brain? 🧠
Delayed ischemic postconditioning performed hours after stroke significantly reduces brain damage in rats, offering a wider therapeutic window than rapid postconditioning and potentially counteracting tPA side effects.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
