Sunday, November 30, 2025

Apolipoprotein E4 Frequencies in a Japanese Population with Alzheimer’s Disease and Dementia with Lewy Bodies

Authors: Seiju Kobayashi, Masaru Tateno, Tae Woo Park, Kumiko Utsumi, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai, Toshikazu Saito

DOI: 10.1371/journal.pone.0018569

Abstract Summary

New study confirms APOE ε4 as a significant risk factor for both Alzheimer’s disease and dementia with Lewy bodies. Using advanced imaging techniques for accurate diagnosis, researchers found similar APOE ε4 frequencies in AD (47-50% carrier rate) and DLB (42%) compared to controls (18%), validating previous autopsy findings.

Why Brain? 🧠

Study confirms APOE ε4 gene variant increases risk for both Alzheimer’s disease and dementia with Lewy bodies in Japanese patients, using advanced imaging to ensure accurate diagnosis.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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