Apolipoprotein E4 Frequencies in a Japanese Population with Alzheimer’s Disease and Dementia with Lewy Bodies

Authors: Seiju Kobayashi, Masaru Tateno, Tae Woo Park, Kumiko Utsumi, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai, Toshikazu Saito

DOI: 10.1371/journal.pone.0018569

Abstract Summary

New study confirms APOE ε4 as a significant risk factor for both Alzheimer’s disease and dementia with Lewy bodies. Using advanced imaging techniques for accurate diagnosis, researchers found similar APOE ε4 frequencies in AD (47-50% carrier rate) and DLB (42%) compared to controls (18%), validating previous autopsy findings.

Why Brain? 🧠

Study confirms APOE ε4 gene variant increases risk for both Alzheimer’s disease and dementia with Lewy bodies in Japanese patients, using advanced imaging to ensure accurate diagnosis.

License: CC BY.

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