Amyotrophic Lateral Sclerosis Is Associated with Hypolipidemia at the Presymptomatic Stage in Mice

Authors: Sung-Min Kim, Heejaung Kim, Jee-Eun Kim, Kyung Seok Park, Jung-Joon Sung, Seung Hyun Kim, Kwang-Woo Lee

DOI: 10.1371/journal.pone.0017985

Abstract Summary

Study reveals low cholesterol levels appear early in ALS mice, before symptoms emerge, suggesting it’s linked to the disease mechanism rather than muscle degeneration. Male mice showed significantly lower LDL and total cholesterol versus controls, occurring without malnutrition or changes in glucose levels. Findings indicate hypolipidemia may be a core metabolic feature of ALS pathology.

Why Brain? 🧠

Study reveals hypolipidemia occurs before ALS symptoms appear in mice, suggesting it may be linked to disease mechanisms rather than just muscle degeneration, with implications for early detection.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.