Authors: Zongqi Xia, Lori B. Chibnik, Bonnie I. Glanz, Maria Liguori, Joshua M. Shulman, Dong Tran, Samia J. Khoury, Tanuja Chitnis, Todd Holyoak, Howard L. Weiner, Charles R. G. Guttmann, Philip L. De Jager
DOI: 10.1371/journal.pone.0014169
Abstract Summary
A genetic variant linked to Alzheimer’s disease risk may also accelerate brain atrophy in multiple sclerosis patients. Researchers found that MS patients carrying the PCK1 gene variant associated with AD showed significantly smaller brain volumes and higher lesion loads. This discovery suggests shared neurodegenerative mechanisms between these two distinct conditions, potentially opening new avenues for understanding and treating brain deterioration in MS.
Why Brain? ðŸ§
MS patients with an Alzheimer’s risk gene variant in PCK1 show greater brain atrophy, suggesting shared neurodegenerative mechanisms between multiple sclerosis and Alzheimer’s disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
