Authors: Chiao-Yin Sun, Shih-Chung Chang, Mai-Szu Wu
DOI: 10.1371/journal.pone.0034026
Abstract Summary
Uremic toxins indoxyl sulfate and p-cresol sulfate drive chronic kidney disease progression by activating the renal renin-angiotensin system and TGF-β pathway, triggering epithelial-to-mesenchymal transition in kidney tubules. Studies in mice showed losartan treatment significantly reduced kidney fibrosis, suggesting RAAS blockade as a potential therapeutic strategy.
Why Brain? 🧠
Uremic toxins indoxyl sulfate and p-cresol sulfate worsen chronic kidney disease by activating the kidney’s renin-angiotensin system, triggering cell transformation and fibrosis that losartan can block.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
