Authors: Maud Racapé, Jean-Paul Duong Van Huyen, Richard Danger, Magali Giral, Françoise Bleicher, Yohann Foucher, Annaïck Pallier, Paul Pilet, Petra Tafelmeyer, Joanna Ashton-Chess, Emilie Dugast, Ségolène Pettré, Béatrice Charreau, Jean-Paul Soulillou, Sophie Brouard
DOI: 10.1371/journal.pone.0019321
Abstract Summary
Researchers identified SMILE/TMTC3, a protein elevated in kidney transplant patients who maintain healthy grafts without immunosuppressive drugs. The study reveals SMILE regulates cellular stress responses in the endoplasmic reticulum by modulating proteasome activity. This discovery may explain how some patients achieve transplant tolerance and could lead to new strategies for long-term graft acceptance.
Why Brain? 🧠
SMILE/TMTC3 protein, elevated in transplant patients who naturally accept organs without immunosuppression, regulates cellular stress responses and may explain tolerance mechanisms in transplantation.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
