Sunday, November 30, 2025

Mixed Organic Solvents Induce Renal Injury in Rats

Authors: Weisong Qin, Zhongxiu Xu, Yizhou Lu, Caihong Zeng, Chunxia Zheng, Shengyu Wang, Zhihong Liu

DOI: 10.1371/journal.pone.0045873

Abstract Summary

Inhalation exposure to mixed organic solvents (gasoline, dimethylbenzene, formaldehyde) caused significant kidney damage in rats, affecting both tubular and glomerular structures. Proteinuria developed after 5-6 weeks, with proximal tubular injuries appearing first, followed by podocyte damage. The study reveals occupational solvent exposure poses serious nephrotoxic risks.

Why Brain? đź§ 

Inhaled mixed organic solvents cause kidney damage in rats, affecting tubular cells first then glomeruli, with proteinuria developing after 5-6 weeks—important for occupational health safety.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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