Authors: Marina A. Aleksinskaya, Ernst E. H. van Faassen, Jelly Nelissen, Ben J. A. Janssen, Jo G. R. De Mey, Roeland Hanemaaijer, Ton Rabelink, Anton Jan van Zonneveld
DOI: 10.1371/journal.pone.0057761
Abstract Summary
Researchers directly measured nitric oxide (NO) in bone marrow for the first time using advanced spectroscopy techniques. They found that NO levels correlate with MMP9, a key enzyme for stem cell mobilization. In hypertensive rats, impaired NO signaling may explain poor stem cell release from bone marrow—a defect potentially treatable with drugs.
Why Brain? 🧠
First direct detection of nitric oxide in bone marrow reveals impaired stem cell mobilization in hypertension, potentially correctable with drugs, offering new therapeutic targets for cardiovascular disease.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
