Sunday, November 30, 2025

Effects of Hemodiafiltration and High Flux Hemodialysis on Nerve Excitability in End-Stage Kidney Disease

Authors: Ria Arnold, Bruce A. Pussell, Timothy J. Pianta, Virginija Grinius, Cindy S-Y. Lin, Matthew C. Kiernan, James Howells, Meg J. Jardine, Arun V. Krishnan

DOI: 10.1371/journal.pone.0059055

Abstract Summary

Hemodiafiltration (HDF) shows promise for managing peripheral neuropathy in end-stage kidney disease patients. This study found nerve excitability measures were significantly closer to normal in HDF-treated patients compared to high-flux hemodialysis, both during single sessions and over 18 months. These findings suggest HDF may better preserve nerve function in dialysis patients.

Why Brain? 🧠

Hemodiafiltration maintains nerve function closer to normal compared to high-flux hemodialysis in kidney failure patients, offering a promising approach to prevent peripheral neuropathy complications.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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