Authors: Mardjaneh Karbalaei Sadegh, Mari Ekman, Catarina Rippe, Bengt Uvelius, Karl Swärd, Sebastian Albinsson
DOI: 10.1371/journal.pone.0035882
Abstract Summary
MicroRNAs regulate bladder smooth muscle function, impacting urination patterns. Researchers used Dicer knockout mice with reduced miRNA levels and found disrupted voiding, weakened bladder contractions, and decreased cholinergic nerve responses. The study revealed reduced expression of key proteins including L-type calcium channels, suggesting miRNAs are crucial for normal bladder contractility and potential therapeutic targets.
Why Brain? 🧠
Study reveals microRNAs regulate bladder muscle function and urination patterns through calcium channels and contractile proteins, offering insights into potential therapeutic targets for bladder disorders.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
