Monday, December 1, 2025

A Blueberry-Enriched Diet Attenuates Nephropathy in a Rat Model of Hypertension via Reduction in Oxidative Stress

Authors: Carrie M. Elks, Scott D. Reed, Nithya Mariappan, Barbara Shukitt-Hale, James A. Joseph, Donald K. Ingram, Joseph Francis

DOI: 10.1371/journal.pone.0024028

Abstract Summary

A blueberry-enriched diet protected kidneys and lowered blood pressure in hypertensive rats. After 6-12 weeks, rats showed improved kidney function, reduced oxidative stress, and enhanced antioxidant defenses. Interestingly, short-term exposure (2 days) initially increased oxidative stress—a “hormetic” response that triggered long-term protective benefits.

Why Brain? 🧠

Blueberry-enriched diet reduces kidney damage in hypertensive rats by lowering oxidative stress, improving blood pressure and kidney function, suggesting natural antioxidants may help prevent hypertension-related organ injury.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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