Authors: Cui Z, Lei X, Gou Y, Wu Z, Huang X.
DOI: 10.1371/journal.pcbi.1013566
Abstract Summary
Researchers identified 22 genes with prognostic value in pancreatic cancer through analysis of 615 tumors. OCIAD2 emerged as a key biomarker, highly expressed in ductal cells of primary and metastatic tumors. Knocking down OCIAD2 reduced cancer cell growth by affecting JAK-STAT and cell cycle pathways. The study also identified 25 compounds targeting OCIAD2, suggesting it could serve as both a prognostic marker and therapeutic target for pancreatic cancer patients.
Why Brain? ðŸ§
OCIAD2 identified as promising pancreatic cancer biomarker through analysis of 944 samples. High expression in tumor cells correlates with poor prognosis; knockdown reduces cancer growth via JAK-STAT pathway.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
