Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome.

Authors: Wong P, Li R, Li D, Fang B, Lan Y, Qi Y, Zheng J, Mo H.

DOI: 10.3389/fmolb.2025.1719463

Abstract Summary

Chaihu-Longgu-Muli decoction (CLMD), a traditional Chinese medicine, shows promise for treating premenstrual syndrome. Using machine learning and network pharmacology, researchers identified 204 active components targeting inflammatory pathways. Key compounds like quercetin and kaempferol modulate IL6, TNF, and IL1B targets, reducing inflammation—a mechanism validated in cell studies.

Why Brain? 🧠

Study reveals how traditional Chinese herbal formula CLMD treats perimenopausal syndrome by targeting inflammation through multiple pathways, validated using AI-assisted analysis and lab experiments.

License: CC BY.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.