Authors: Liu Y, Zeng X, Lyu Z, Huang D.
DOI: 10.3389/fmicb.2025.1720153
Abstract Summary
Carcinogenic microorganisms hijack the host’s ubiquitin-proteasome system to drive cancer development. HPV, HBV, HCV, EBV, and KSHV employ distinct strategies—degrading tumor suppressors, evading immune surveillance, and activating growth pathways through ubiquitin modifications. Non-viral agents like H. pylori also exploit these mechanisms. Understanding this shared strategy offers promising targets for precision cancer therapies.
Why Brain? đź§
Carcinogenic microbes hijack cellular protein modification systems to drive cancer development, with viruses like HPV degrading tumor suppressors and evading immune detection, revealing new precision therapy targets.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
