Authors: DeBerardinis RJ, Vousden KH, Chandel NS.
DOI: 10.1101/cshperspect.a041555
Abstract Summary
Cancer metabolism research has evolved beyond Warburg’s century-old observations, but critical questions remain. Scientists now face three key challenges: understanding how metabolism operates across cellular, tissue, and organ compartments; tracking how tumors’ metabolic needs change from early lesions to metastatic disease; and translating laboratory findings into effective patient therapies.
Why Brain? ๐ง
New cancer metabolism insights bridge Warburg-era questions to future therapies, targeting metabolic compartmentalization, tumor evolution, and translating preclinical findings into patient treatments.
Study Limitations:
Study limitations were not specified in the abstract.
License: cc by.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
