Variability of Bio-Clinical Parameters in Chinese-Origin Rhesus Macaques Infected with Simian Immunodeficiency Virus: A Nonhuman Primate AIDS Model

Authors: Song Chen, Chunhui Lai, Xiaoxiang Wu, Yaozheng Lu, Daishu Han, Weizhong Guo, Linchun Fu, Jean-Marie Andrieu, Wei Lu

DOI: 10.1371/journal.pone.0023177

Abstract Summary

Study of 150 Chinese rhesus macaques reveals key differences in SIV infection models for AIDS research. SIVmac239 caused 30-fold higher viral loads and faster disease progression than SIVmac251, with lower variability enabling smaller study groups. Findings provide crucial data for standardizing preclinical AIDS vaccine and therapy trials.

Why Brain? 🧠

Study establishes standardized Chinese rhesus macaque SIV model showing SIVmac239 requires half the animals of SIVmac251 for vaccine testing due to lower variability in viral loads.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.