Authors: Fabio Schneider Ribeiro, Isabel Caetano de Abreu da Silva, Vitor Coutinho Carneiro, Fabrício dos Santos Belgrano, Ronaldo Mohana-Borges, Ivone de Andrade Rosa, Marlene Benchimol, Nathalia Rocha Quintino Souza, Rafael Dias Mesquita, Marcos Henrique Ferreira Sorgine, Felipe Gazos-Lopes, Amanda Roberta Revoredo Vicentino, Wenjie Wu, Renata de Moraes Maciel, Mario Alberto Cardoso da Silva-Neto, Marcelo Rosado Fantappié
DOI: 10.1371/journal.pone.0040192
Abstract Summary
Researchers characterized HMGB1 protein in Aedes aegypti mosquitoes, vectors of dengue and yellow fever. The protein features a unique alanine/glutamine-rich region that regulates DNA binding and bending. Phosphorylation by PKA or PKC completely blocks its DNA activity, revealing novel regulatory mechanisms that could inform mosquito control strategies.
Why Brain? 🧠
Study identifies unique HMGB1 protein in dengue mosquitoes with novel regulatory features, offering potential new targets for vector control strategies against dengue, chikungunya, and yellow fever.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
