Authors: Dahai Zheng, Gino V. Limmon, Lu Yin, Nicola H. N. Leung, Hanry Yu, Vincent T. K. Chow, Jianzhu Chen
DOI: 10.1371/journal.pone.0048451
Abstract Summary
Following severe lung injury, Clara cells—identified by Scgb1a1 expression—serve as key progenitors for regenerating alveolar epithelia. Using transgenic mice, researchers found that after bleomycin or influenza-induced damage, most newly formed type I and II alveolar cells originated from these Clara cells, revealing their critical role in lung repair and recovery.
Why Brain? 🧠
Study identifies Clara cells as key progenitors regenerating damaged lung tissue after severe injury, offering insights into lung repair mechanisms and potential therapeutic targets for acute lung diseases.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
