Authors: Ben Murrell, Tulio de Oliveira, Chris Seebregts, Sergei L. Kosakovsky Pond, Konrad Scheffler
DOI: 10.1371/journal.pcbi.1002507
Abstract Summary
Researchers developed new models (MEDS and EDEPS) to detect episodic directional selection in HIV-1 drug resistance evolution. These models outperform existing methods by identifying resistance sites more accurately while maintaining low false positives, better capturing how resistance mutations emerge during antiretroviral therapy rather than evolving continuously.
Why Brain? ðŸ§
New models detect HIV drug resistance mutations more accurately by combining episodic and directional selection, outperforming existing methods in identifying resistance sites during antiretroviral therapy.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
