Authors: Yongliang Zhu, Qiaoli Jiang, Xiaojun Lou, Xiaowei Ji, Zhenzhen Wen, Jia Wu, Haiying Tao, Tingting Jiang, Wei He, Caihua Wang, Qin Du, Shu Zheng, Jianshan Mao, Jian Huang
DOI: 10.1371/journal.pone.0035147
Abstract Summary
H. pylori’s cancer-causing CagA protein triggers two microRNAs (miR-584 and miR-1290) that disrupt normal cell differentiation in gastric tissue. These microRNAs create a self-reinforcing loop through Erk1/2 and NF-κB signaling, target the Foxa1 protein, and promote precancerous intestinal metaplasia in mice—revealing a novel mechanism for CagA-driven gastric cancer development.
Why Brain? 🧠
H. pylori’s CagA protein triggers specific microRNAs that cause precancerous intestinal metaplasia in stomach cells, revealing a novel molecular pathway linking bacterial infection to gastric cancer development.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
