Authors: Nanyu Han, Xuewei Liu, Yuguang Mu
DOI: 10.1371/journal.pone.0044057
Abstract Summary
Researchers reveal how a single mutation (Q136K) in H1N1 influenza neuraminidase causes resistance to Zanamivir, an antiviral drug. Using molecular simulations, they found the mutation disrupts protein structure and weakens drug binding by altering hydrogen bonds and deforming a critical loop region. The study highlights structural changes as key resistance mechanisms.
Why Brain? ðŸ§
H1N1 mutation Q136K causes Zanamivir resistance by disrupting protein structure and drug binding. Understanding this mechanism helps develop new treatments for drug-resistant influenza strains.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
