Sunday, January 18, 2026

Developmental Transcriptomic Features of the Carcinogenic Liver Fluke, Clonorchis sinensis

Authors: Won Gi Yoo, Dae-Won Kim, Jung-Won Ju, Pyo Yun Cho, Tae Im Kim, Shin-Hyeong Cho, Sang-Haeng Choi, Hong-Seog Park, Tong-Soo Kim, Sung-Jong Hong

DOI: 10.1371/journal.pntd.0001208

Abstract Summary

Researchers mapped gene expression across three life stages of Clonorchis sinensis, a liver fluke infecting 15 million people in Asia. The study revealed stage-specific genes: adults showed high metabolism and reproduction activity, metacercariae expressed host-adaptation genes, and eggs displayed embryonic genes. These findings illuminate how the parasite survives and may lead to new drug targets.

Why Brain? 🧠

Study maps gene expression across life stages of liver fluke causing cancer, revealing stage-specific metabolic patterns that could lead to new drug targets for treating 15 million infected patients.

License: CC BY.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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