Saturday, December 6, 2025

Comparison of Xpert MTB/RIF with Other Nucleic Acid Technologies for Diagnosing Pulmonary Tuberculosis in a High HIV Prevalence Setting: A Prospective Study

Authors: Lesley E. Scott, Kerrigan McCarthy, Natasha Gous, Matilda Nduna, Annelies Van Rie, Ian Sanne, Willem F. Venter, Adrian Duse, Wendy Stevens

DOI: 10.1371/journal.pmed.1001061

Abstract Summary

A real-world study within a national TB screening program compared Xpert MTB/RIF testing on single sputum samples against other tuberculosis detection methods. The research by Lesley Scott and team evaluated diagnostic performance across different technologies to determine the most effective approach for TB screening.

Why Brain? 🧠

Xpert MTB/RIF test on single sputum sample effectively diagnoses tuberculosis in HIV-endemic areas, offering faster, more accurate detection than traditional methods in real-world screening programs.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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