Authors: Eduardo Iglesias-Gutiérrez, Brendan Egan, Ángel Enrique Díaz-Martínez, José Luis Peñalvo, Antonio González-Medina, Pablo Martínez-Camblor, Donal J. O’Gorman, Natalia Úbeda
DOI: 10.1371/journal.pone.0051185
Abstract Summary
Acute exercise temporarily raises homocysteine levels in sedentary men, peaking after 400 kcal expenditure regardless of intensity, then declining to baseline within 24 hours. Importantly, levels never reached harmful thresholds when participants had adequate B-vitamin status, suggesting exercise poses no cardiovascular risk even at high intensity for those with proper nutrition.
Why Brain? 🧠
Acute exercise temporarily raises homocysteine levels but doesn’t cause harmful hyperhomocysteinemia in sedentary people when nutrition is adequate, supporting exercise safety for heart health.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
