Three-Dimensional Modeling of Glucose-6-phosphate Dehydrogenase-Deficient Variants from German Ancestry

Authors: Farooq Kiani, Sonja Schwarzl, Stefan Fischer, Thomas Efferth

DOI: 10.1371/journal.pone.0000625

Abstract Summary

German G6PD enzyme variants differ from Mediterranean and African forms, suggesting independent evolution. Using 3D modeling, researchers found mutations cluster near glucose-6-phosphate and NADP+ binding sites or monomer interfaces, potentially disrupting enzyme function. This rare enzymopathy in Germany affects 400 million globally.

Why Brain? 🧠

Study maps 3D structures of rare German G6PD deficiency variants, revealing unique mutations distinct from Mediterranean/African types, advancing understanding of this common metabolic disorder affecting 400 million globally.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.