Authors: Hauke Rühs, Achim Becker, Anne Drescher, John C. Panetta, Ching-Hon Pui, Mary V. Relling, Ulrich Jaehde
DOI: 10.1371/journal.pone.0046015
Abstract Summary
Researchers developed a model tracking how high-dose methotrexate chemotherapy elevates homocysteine levels in 494 children with leukemia. The study found age affects baseline homocysteine, and while folinate rescue therapy doesn’t prevent peak homocysteine spikes, it modestly reduces overall exposure—offering insights to optimize treatment safety.
Why Brain? 🧠
Study develops model predicting homocysteine levels during leukemia treatment, helping optimize folinate rescue therapy to reduce methotrexate neurotoxicity risk in children with acute lymphoblastic leukemia.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
