Authors: Jian feng Zhu, Zi jian Li, Guang sen Zhang, Kun Meng, Wen yong Kuang, Jin Li, Xin fu Zhou, Rui juan Li, Hong ling Peng, Chong wen Dai, Jian Kai Shen, Fan jie Gong, Yun xiao Xu, Su fang Liu
DOI: 10.1371/journal.pone.0023720
Abstract Summary
Icaritin, a compound from Chinese herbal medicine, shows promise against chronic myeloid leukemia (CML). It inhibits CML cell growth, triggers cancer cell death, and works even against Imatinib-resistant cells. In mice, it extended survival as effectively as Imatinib without bone marrow suppression. Icaritin targets downstream cancer signaling pathways rather than the Bcr/Abl protein itself, suggesting potential as an alternative treatment for drug-resistant CML.
Why Brain? ðŸ§
Icaritin, a Chinese herbal compound, effectively kills chronic myeloid leukemia cells including drug-resistant types by targeting key cancer pathways, offering a promising alternative treatment option.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
