Authors: Asmita Kulkarni, Kamini Dangat, Anvita Kale, Pratiksha Sable, Preeti Chavan-Gautam, Sadhana Joshi
DOI: 10.1371/journal.pone.0017706
Abstract Summary
High folic acid intake without adequate vitamin B12 may harm pregnancy outcomes by lowering DHA levels in the placenta and altering DNA methylation patterns. However, omega-3 supplementation can reverse these effects, restoring healthy methylation levels. This finding is particularly relevant for vegetarian populations at risk of B12 deficiency.
Why Brain? ðŸ§
Excess folic acid without B12 lowers placental DHA and DNA methylation in rats. Omega-3 supplementation reverses this effect, revealing DHA’s role in regulating placental DNA methylation patterns.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
