Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets

Authors: Osama A. Hamad, Per H. Nilsson, Maria Lasaosa, Daniel Ricklin, John D. Lambris, Bo Nilsson, Kristina Nilsson Ekdahl

DOI: 10.1371/journal.pone.0012889

Abstract Summary

Researchers found that chondroitin sulfate A (CS-A), exposed on activated platelet surfaces, binds complement proteins C1q, C4BP, and factor H. CS-A-bound C1q amplifies immune complex binding to platelets, suggesting CS-A plays a role in immune complex diseases and adds a new binding mechanism for complement regulation on platelets.

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Chondroitin sulfate A on activated platelets binds complement proteins C1q, C4BP, and factor H, potentially amplifying immune complex binding and suggesting a role in immune complex diseases.

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