Authors: Lucia De Franceschi, Giovanni Scardoni, Carlo Tomelleri, Adrian Danek, Ruth H. Walker, Hans H. Jung, Benedikt Bader, Sara Mazzucco, Maria Teresa Dotti, Angela Siciliano, Antonella Pantaleo, Carlo Laudanna
DOI: 10.1371/journal.pone.0031015
Abstract Summary
Researchers used advanced protein analysis to uncover how abnormal “thorny” red blood cells form in two rare neurodegenerative disorders, McLeod syndrome and chorea-acanthocytosis. By mapping protein interaction networks, they identified 14 key signaling molecules that likely drive these cellular changes, offering new insights into disease mechanisms and potential therapeutic targets.
Why Brain? ðŸ§
Study identifies 14 key signaling proteins linked to abnormal red blood cell formation in rare neurodegenerative disorders, offering potential biomarkers and therapeutic targets for neuroacanthocytosis.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
